Monday, January 22, 2018

Genethics and Ethics: Finished!

Tonight I finally finished all the revisions to my latest book Genetic Ethics: An Introduction.

Over my 18 year academic career I have never worked so intensely on just one project as I have in the last year on this book. I typically have 3-4 different things I work on simultaneously, but over the last 12 months I have worked solely on completing this book (with the exception of 1 invited chapter I wrote the draft of 2 months ago). While this new book is on the same topic as Biologically Modified Justice, I decided to address the ethical and social implications of the genetic revolution from a completely different moral lens than the one adopted in that earlier book. In many ways this introductory book profited immensely from the hard lessons I learned spending 16 years writing Biologically Modified Justice first. So starting this new book with a fresh normative lens, and aspiring to reach a broad audience of students in the humanities/social sciences and life and medical sciences, proved to be the catalyst I needed to generate more new ideas on the topic.

Here is the table of contents (book totals about 68,000 words):

Table of Contents

Introduction
Chapter 1: Eugenics: Inherently Immoral?
Chapter 2: The Genetic Revolution: A Snapshot
Chapter 3: Disease
Chapter 4: Epigenetics
Chapter 5: Reproductive Freedom
Chapter 6: Aging Research and Longevity
Chapter 7: Happiness, Memory and Behaviour
Conclusion
Bibliography


And here is a sample from the final few paragraphs in the Concluding chapter:

The biology of humans has a long and varied evolutionary history. A history shaped by the hazards of the external world, such as infectious disease, scarcity of food, intergroup conflict, etc. And humans have crafted various forms of social engineering to help redress or minimize some of these external risk factors. Public health and preventative medicine, democratic governance, market economies, these are all forms of social engineering that have shaped a culture that, indirectly, influenced the biology of humans. Technological innovations in food production, coupled with a global economy, mean that billions of (but not all) people in the world today have been emancipated from the daily hunger and risks of starvation which would have been typical for many humans living in earlier historical epochs. And yet, in developed countries, the abundance of relatively cheap high-calorie, low-nutrient foods and beverages has increased the incidence of childhood obesity. Social engineering of any kind- whether it be to modify the technologies of food production, or political governance or expedite economic growth, is not necessarily all-good or even desirable. A virtuous polity must continuously modify, refine and improve the forms of social engineering it employs, to improve its knowledge and technology so that individuals and the polity itself can flourish, rather than flounder.

“Genetically engineering” humans, via gene therapy or genome editing or a drug that modulates aging by activating the “longevity genes”, is yet one further possible form of social engineering. The critic might ask why should we should seriously consider adding genetic intervention into the possible mix of technologies humans pursue. Our response can highlight the prevalence of genetic disorders, from early onset single gene conditions, to more common multi-factorial conditions. The genes we inherit influence not only our health, but also our intelligence, behavior (e.g. parent investment), happiness and how we age. The genetic revolution might permit humans to intentionally intervene in the genetic lottery of life in a way that improves our life prospects much further than what could be realized if we left our biology to the blind and arbitrary process of evolution by natural selection.

By reducing mortality from infectious diseases, and developing medical procedures and pharmaceuticals that permit us to manage multi-morbidity in late life, humans can now survive beyond the “biological warranty period” of seven decades. The aging of human populations is a very new and novel phenomenon and one that demonstrates how important the epistemic virtue of adaptability of intellect is if we hope to improve the health prospects of an aging world. New knowledge about our genes might prove to be foundational in developing the health innovations needed to realize greater equality, health and economic prosperity for all of the world’s diverse populations.


As with other intellectual projects I have completed, it is a somewhat bitter sweet feeling. Sweet to be able to feel the sense of accomplishment in completing something so ambitious and arduous. But at the same time, it is a bit bitter because it leaves a gaping whole in one's life when something that has consumed so much of one's time, thought and energy is finally completed. The next major project will get under serious way in the fall when I am on sabbatical. Until then, 3 classes to finish teaching this term, a book chapter to revise, and a presentation on play and happiness to prepare and present at Harvard in the spring term. So I am sure I will find ways to keep myself busy!

Fingers crossed that this book makes it out in print for the summer!

Cheers,
Colin